Dados do Trabalho

Title

Effects of Clomiphene Citrate on Hormonal and Seminal Parameters in Men Diagnosed with Oligozoospermia.

Objective

This study aimed to assess the therapeutic response to clomiphene citrate (CC) in men diagnosed with oligozoospermia at a human reproduction center.

Methods

A retrospective analysis of medical records was conducted, focusing on the hormonal profile (total testosterone - TT, estradiol - E2, follicle-stimulating hormone - FSH, luteinizing hormone - LH) and semen analysis before and after CC treatment. The variations in values were expressed as Δ% = [(final value - initial value) / initial value] x 100.

Results

Semen analyses analysis revealed that 45.5% of patients exhibited isolated improvements in sperm concentration, while 31.8% demonstrated enhanced progressive motility.
Hormonal profile analysis indicated a 90% increase in total testosterone after treatment, with a mean variation (ΔTT) of 68.6%. Among patients with elevated testosterone levels, 22.2% showed a ΔTT less than 20%.
Estradiol levels increased in 87.5% of patients, with a ΔE2 of 43.3%. A decline in the total testosterone/estradiol ratio was observed in 25% of patients; however, only 16.7% had ratio values below 10 after treatment.
FSH levels were elevated in 72.7% of patients, with a ΔFSH of 45.5%. LH levels were increased in 81% of patients, with a ΔLH of 58.7%. Among the 19% of patients who showed a reduction in LH after treatment, no evidence of a decrease in testosterone levels was observed.

Conclusion

Clomiphene citrate represents a cost-effective, well-tolerated, and user-friendly option that leads to improvements in seminal parameters in semen analysis for men diagnosed with oligozoospermia.

Keywords

Male Infertility, Clomiphene Citrate, Sperm