Dados do Trabalho

Title

THE INFLUENCE OF OBESITY ON IN VITRO FERTILIZATION RESULTS: A SYSTEMATIZED REVIEW

Objective

To systematically analyze in the literature, the influence of obesity on the results of in vitro fertilization.

Methods

For the study, the BVS and PUBMED databases were consulted. In the selection of articles, the keywords “Obesity” and “IVF” were used, articulated with the Boolean operator “AND”. The filter “the last 5 years” was used. In BVS, 96 articles were found and in PUBMED, 250 were found. 4 articles from PUBMED and 3 from BVS were read according to the greatest alignment with the research proposal. The conduct used for data extraction was the analysis of the results of the searches carried out in the databases, this analysis was made from the reading of the articles.

Results

Obesity in IVF influences the reduction of live birth rates and increased abortion rates when compared to non-obese women. This occurs because, when comparing the groups, there is a reduction in the quality of oocytes and a lower endometrial receptivity in women with obesity. At first, it was believed that abortions in obese patients could be caused by greater numbers of aneuploid embryos, but through the study it was found that the PGT-A cycles, days of stimulation and number of collected MII oocytes do not show significant changes between obese and non-obese women, with changes only in the amount of gonadotropins, which in obese women require higher dosages. This finding demonstrates that the origin of the increased rate of pregnancy loss after IVF, in these women with euploid embryos, may be related to epigenetic or mitochondrial disturbances of oocytes and embryos, or be secondary to an abnormal uterine environment, fed by an environment inflammation characteristic of obesity.

Conclusion

Therefore, it is noticeable that obesity and high body mass indexes (BMI) negatively influence the implantation and development of the embryo in women undergoing in vitro fertilization. In these cases, the articles read demonstrated an increase in the rates of abortion and stillbirths in women with obesity and a reduction in the success of the IVF procedure.

Keywords

Obesity; IVF.