Dados do Trabalho

Title

Elevated progesterone on trigger day has no impact on blastulation rate

Objective

To evaluate the effect of serum progesterone level on the hCG trigger day on blastulation rate.

Methods

This retrospective analysis included IVF/ICSI cycles performed from January 2022 to June 2023 that underwent extended culture to the blastocyst stage. Patients were divided into two groups according to the serum progesterone level on the hCG trigger day: control (<1,5 ng/mL) and elevated progesterone (study group, ≥1,5 ng/mL). The primary outcome of this study was blastulation rate. Antral follicle count, AMH, number of oocytes retrieved and fertilization rate were also compared.

Results

A total of 81 IVF/ICSI cycles were included in this study. Mean serum progesterone level in the control group (n=58) was 0.86 ng/mL and 2.178 ng/mL in the study group (n=23). As expected, since AMH and progesterone are both products of the ovarian granulosa cells, AMH was higher in the elevated progesterone group [4.20 ng/mL ± 3.17 vs 2.45 ng/mL ± 1.89 (p=0.003)], as well as the antral follicle count [14.3 ± 5.0 vs 11.8 ± 6.1 (p=0.052)] and the number of oocytes retrieved [16.0 ± 8.5 vs 10.4 ± 6.5 (p=0.001)]. There was no statistical difference in the fertilization rate [88,5% ± 0.16 vs 88,5% ± 0.15 (p=0.715)], nor in the blastulation rate [47,8% ± 0.35 vs 41% ± 0.28 (p = 0.498)] between control and study groups, respectively. We also performed a multivariable analysis, which confirmed our findings that blastulation and increased progesterone on the hCG day are not associated.

Conclusion

Our results indicated that serum progesterone above 1,5 ng/mL on hCG trigger day has no association with blastulation rate.

Keywords

progesterone, trigger day, blastulation rate