Dados do Trabalho

Title

The importance of Key Performance Indicators (KPI's) for tracking deviations in results.

Objective

To demonstrate the importance of using and analyzing KPI's, in order to identifying possible problems that could affect laboratory rates.

Methods

The KPI's used to evaluate the laboratory results were selected based on the Vienna Consensus, namely: fertilization rate >65%, D3 cleavage 45%, blastocyst development >40% and implantation >35%. Based on the laboratory routine, the analysis of the results is carried out monthly. In a retrospective evaluation, a decrease in the rate of evolution to Blastocyst was evidenced, so that, according to the quality parameter of the center, a non-compliance was generated. Some of the following interferences were included: laboratory environment, operator, incubator, disposable materials, mineral oil and culture medium

Results

Regarding the analysis of the laboratory environment, the air certification parameters, temperature and humidity were satisfactory. From operator analysis, the rates of fertilization and embryo manipulation did not demonstrated variations in rates between operators. There was no difference between the incubators used for embryos culture, as well there was no exchange of gas cylinders used. Disposable materials and mineral oil did not change. Regarding the traceability of the culture medium, it were evidenced that the type of medium was changed, from sequential to single, both being from the same manufacturer and having a pH value within the recommendation. This was the only modification made in this period. Corrective action of the culture medium was carried out with reestablishment of blastulation results in the following month.

Conclusion

Currently, there are several culture medium available on the market, with scientifically satisfactory results, however, it depends on each laboratory to assess which one best supports embryologic development within its reality. Unforeseen circumstances in the laboratory routine occur, so that alternatives need to be taken quickly. Therefore, it is important to maintain strict quality control with properly documented materials and processes. Quality indicators, combined with good quality management, make it possible to quantify, monitor and constantly improve results. These are essential for patient safety and laboratory autonomy, allowing early detection of problems and the adoption of corrective actions. Any variable, no matter how small, will be observed and quickly controlled, avoiding clinical impact.

Keywords

Internal Quality Control, Human Reproduction; Laboratory.