Dados do Trabalho

Title

Successful ultrasound guided extracorporeal mature oocyte cryopreservation after ovarian cancer

Objective

Ovarian cancer is a challenge for fertility preservation because of the risks of tumoral cell spillage in a traditional transvaginal oocyte pick-up. The possibility of aspirating follicles directly from the ovarian specimen already excised is an option in this scenario.

Methods

Case report of successful ultrasound guided extracorporeal mature oocyte cryopreservation after ovarian cancer.

Results

A 23 year old woman with a past history of ovarian dysgerminoma treated conservatively with unilateral right oophorectomy presented with tumor recurrence in the remaining ovary. The patient underwent ovarian stimulation followed by laparotomy and left oophorectomy, scheduled accordingly to follicular development and predicted egg retrieval. Follicular aspiration was performed under direct ultrasound guidance in the operation room and follicular fluid was transported in a heated device to the IVF lab within a maximum ischemia time of 63 minutes. A total of 11 mature oocytes were vitrified and an additional number of 4 immature oocytes were submitted to in vitro maturation (IVM) and also vitrified.

Conclusion

Mature oocytes can be retrieved from an oophorectomy specimen after controlled ovarian hyperstimulation, reducing the risk of cancer cell spillage associated with the standard procedure.

Keywords

Ovarian cancer, fertility preservation, germ cell tumor, egg freezing,