Dados do Trabalho

Title

Dydrogesterone versus GnRH Antagonist: Comparative study in normal responders submitted to ovarian stimulation in IVF cycles

Objective

Ovarian stimulation is a fundamental part of assisted human reproduction treatment cause it enables multiple recruitment and follicular maturation to capture oocytes. Currently, assisted reproduction clinics can rely on several protocols to promote the best result for the patient. Drugs that act as GnRH agonists or antagonists are normally used, but another ovarian stimulation protocol is through the use of progesterone. The objective of this work is to analyze the results of ICSI cycles performed in our unit, to compare the results between the use of GnRH antagonists and the use of dydrogesterone to stimulate ovulation in normal responders.

Methods

This research is a retrospective study involving 183 ICSI cycles performed at Clinica Fertvida – São Luis, between the years 2016-2021. The study groups were divided into 76 patients treated with GnRH antagonist in a short protocol and the second group has 107 patients treated with Dydrogesterone. All patients aged less than 38 years and had a normal hormonal profile. The patients participating in the study didn’t have endometriosis, endometrioma or polycystic ovaries. Data were analyzed by Software R 4.3.1, using the Kruskal-Wallis test with post-hoc in Duun.

Results

No significant difference was observed between the two groups regarding the number of oocytes collected and maturation. A significant difference was seen between the final amount of blastocysts, being greater in the dydrogesterone group

Conclusion

It was observed that the use of progesterone was effective for ovarian stimulation, as well as the use of antagonists. This result is important to assist in our clinical practice.

Keywords

Ovarian hyperstimulation. GnRH antagonists, Progesterone,In vitro fertilization