Dados do Trabalho

Title

OUTCOME OF PREGNANCY RATE ACCORDING TO OOCYTE DONOR BMI

Objective

Suboptimal reproductive outcomes have been associated with increased Body Mass Index (BMI), particularly in assisted reproductive technology (ART). Studies have demonstrated that women who are overweight and obese have lower rates of fertilization, implantation, and pregnancy. The main objective of the present study, therefore, was to assess the outcome of pregnancy rate according to BMI. Knowing that the quality of eggs reduces with advancing age, only oocytes from donor patients were included in this study.

Methods

Retrospective study performed at the ART center Androlab, located in Curitiba, Brazil, with oocytes from donors in the period between January/2021 and June/2023. All patients who transfered embryos originated from a donated oocyte were included in the study. Patients were separated into four groups according to the donor's BMI and the outcomes were analyzed considering positive, negative, and biochemistry results.

Results

The analyzes included a total of 56 donated oocytes. Being 23 oocytes were from donors classified as eutrophic, with a BMI under 24.9. The recipients of this group had an implantation rate of 61% and a pregnancy rate of 65%. Nineteen oocytes were from overweight donors, with a BMI between 25 and 29.9, and reached an implantation rate of 47% and a pregnancy rate of 63%. Eleven oocytes were from donors classified as class I obese, with a BMI between 30 and 34.9, and the recipients had an implantation rate of 27% and a pregnancy rate of 36%. Finally, three oocytes were from donors with a BMI greater than 35, and the recipient had an implantation and a pregnancy rate of 33%.

Conclusion

Despite the difficulty in finding donor candidates, it is interesting to assess the BMI when selecting the patient for donation. Limitations include the retrospective design, sample size, data from a single institution and the combination of the donor oocyte´s BMI and the BMI of the patient who received the embryo. The observations of this study suggest a possible effect of BMI at the oocyte level, before fertilization and implantation, and the need for further investigation. Having a multi-professional team, including a nutritionist, is an important point for the comprehensive treatment of the patient. Considering the results, patients with an increased BMI should be instructed to practice physical activities and regulate their diet before the oocyte donation.

Keywords

BMI, PREGNANCY RATE, DONOR OOCYTE