Dados do Trabalho

Title

Evaluation of the positive beta hCG profile in relation to the mean score of the KIDScore and Mitoscore embryonic analysis systems.

Objective

To verify the profile of positive beta-hCG in relation to the mean KIDScore and Mitoscore scores in patients with reproductive complications.

Methods

This article is a retrospective cohort study that consists of the analysis of medical records of patients undergoing assisted human reproduction procedures at the BIOS human reproduction clinic (Fortaleza-Ce, Brazil). A review of clinical records corresponding to the period from January 1, 2022 to July 1, 2023 was carried out. As main clinical deciders, patients with confirmed diagnoses of endometriosis, tubal factor problems, adenomyosis and male factor problems were selected. Exclusion criteria were: patients with medical records that contained incomplete information and patients with infertility without apparent cause. The entire selection and sorting of medical records was carried out in an automated way from the Gs Doctor system. The data from the present study included the KIDScore and Mitoscore values, in addition to the beta-hCG result and cause of the patient's infertility. To perform the statistical analysis, the statistical package R studio (version 4.2.2) was used. For which, all quantitative data were represented by mean ± standard deviation. Data referring to continuous quantitative variables were calculated using the t test and the significance value adopted was p < 0.05.

Results

In total, 62 patients were selected for analysis according to the inclusion criteria. Of these, 24 were diagnosed with endometriosis, six with problems in the tubal factor, 18 patients with adenomyosis and 14 with complications in the male factor. In patients with endometriosis, the mean between KIDScore values with positive and negative beta was between 6.89 ± 0.43 and 6.92 ± 0.40 respectively, showing no statistical difference (p = 0.95). This was also observed for the mitoscore, which exhibited mean values of 13.94 ± 1.42 and 18.03 ± 1.620 for beta positive and negative patients (p = 0.09). All patients with tubal factor included in the study did not obtain positive beta hCG. Patients diagnosed with adenomyosis also did not show significant differences between the means in the KIDScore values when compared to the beta hCG result (6.48 ± 0.91; 5.60 ± 0.60; p = 0.41). Regarding the mitoscore, beta-positive and beta-negative patients with adenomyosis also did not show significant differences regarding the mean value (14.86 ± 1.69; 15.34 ± 1.97; p = 0.86). Patients with altered male factor did not show a difference between the KIDScore mean and the beta hCG result (6.48 ± 1.18; 6.55 ± 0.99; p = 0.96). The mitoscore value for patients with altered male factor also showed no difference when compared to beta-positive and beta-negative patients respectively (14.04 ± 1.46; 16.09 ± 1.35; p = 0.32).

Conclusion

The present result indicates that the mean between KIDScore and mitoscore scores may not be significantly associated with the rate of clinical pregnancy. However, further studies are needed to confirm this result.

Keywords

Mitoscore; KIDScore; Embryo Transfer; Fertility; Reproductive Technique