Dados do Trabalho

Title

Impact of pre-diabetes on seminal parameters of patients undergoing assisted reproduction techniques: A retrospective analysis of cases from 2017-2018

Objective

To verify the impact of pre-diabetes on the seminal parameters of patients undergoing assisted reproduction techniques (ART).

Methods

The present work is a retrospective cohort study that consists of the analysis of medical records of patients undergoing ART at the human reproduction clinic Evangelista Torquato (Fortaleza-Ce, Brazil). This study was approved by the ethics and research committee involving human beings under protocol number (58462022.8.0000.5054). To carry out the study, clinical records corresponding to the period from January 1, 2017 to December 31, 2018 were verified. diabetes and medical records of apparently fertile couples (control group). As exclusion criteria: Couples in which the partner had a history of adjacent comorbidities that led to infertility and medical records with incomplete information were excluded. The data extracted from the medical records were: patient's age, glycated hemoglobin, sperm concentration in the ejaculate, motility, sperm morphology, and ejaculate volume. Quantitative seminal analysis data were expressed as mean ± standard deviation. Data referring to continuous quantitative variables were calculated using the t-test. In all tests, a significance value of p < 0.05 was adopted. To perform the statistical analysis, the R studio software (version 4.2.2) was used.

Results

Overall, data were obtained from 70 patients in the study: 40 pre-diabetics and 30 patients in the control group. The mean age of patients in the pre-diabetic group was 38.66 ± 1.48 years, while in the control group 38.05 ± 1.28 years and there was no significant difference between them (p = 0.75). The percentage of glycated hemoglobin among pre-diabetic patients was between 5.67 ± 0.04%, while among patients in the control group it was 5.031 ± 0.04%. Our work showed no significant difference between the ejaculate volume parameter of the prediabetic group compared to the control group (2.80 ± 0.27; 3.03 ± 0.20; p = 0.49). The same was also verified in the parameter of sperm concentration whose pre-diabetic group presented a mean of 39.03 ± 6.07 x 106, while the control group presented 45.40 ± 8.73 x 106 (p = 0.46). Furthermore, no correlation was found between sperm motility in prediabetic patients and the control group (37.43 ± 3.00; 42.61 ± 3.17; p = 0.24). Kruger sperm morphology also showed no significant difference between prediabetic and control groups respectively (7.68 ± 1.02; 9.71 ± 2.65; p = 0.24).

Conclusion

Given the above, pre-diabetes conditions may not influence the seminal parameters of patients undergoing ART. However, further studies addressing a larger representative population should be performed in order to validate this hypothesis.

Keywords

Pre-Diabetic Status, Infertility, Semen Analysis, Semen